Réaction #4701

Équation de réaction

N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide

methyl isothiocyanate

Ether

→

N-Methyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]1,2-hydrazine dicarbothioamide

Solvants

THF

Conditions de réaction

Traitement

1. 1
   workup.WAITthe reaction mixture is left
2. 2
   Autrethe precipitate formed
3. 3
   Filtrationfiltered
4. 4
   Lavagewashed with ether
5. 5
   Autrerecrystallised from ethanol

Mode opératoire

1.62 g (5 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carbothioamide are dissolved in 30 ml of THF, 0.44 g (6 mmol) of methyl isothiocyanate are added, and the reaction mixture is left to stand overnight at room temperature. Ether is added to complete precipitation and the precipitate formed is suction filtered, washed with ether and recrystallised from ethanol. The analytical values are summarized in Table I.

Source