Réaction #469172

Équation de réaction

dibromo

2-(3,4-Difluorophenyl)-4,5-dibromo-3(2H)-pyridazinone

3-methyl-1,3-butanediol

→

title intermediate

2-(3,4-Difluorophenyl)-4-(3-hydroxy-3-methyl-1-butoxy)-5-bromo-3(2H)-pyridazinone

Conditions de réaction

Traitement

1. 1
   Autreto selectively react at the 4-position

Mode opératoire

The dibromo-intermediate from Example 471B was reacted according to the procedure described in Example 194B, substituting 3-methyl-1,3-butanediol in place of methanol, to selectively react at the 4-position and provide the title intermediate.

Source