Réaction #4691

Équation de réaction

hydrogen chloride

product

3-ethyl-5-(4-methoxy-phenyl)-4-phenyl-4H-1,2,4-triazole

isopropyl ether

→

3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride

Solvants

ethanol

ethanol

Conditions de réaction

Traitement

1. 1
   FiltrationThe mixture was filtered
2. 2
   Filtrationfiltered
3. 3
   Autrewas dried
4. 4
   workup.DISSOLUTIONThe product was dissolved in 350 ml of tetrahydrofuran
5. 5
   Filtrationthe solution was filtered
6. 6
   Concentrationconcentrated to a volume of 75 ml
7. 7
   TempératureThe mixture was cooled
8. 8
   Filtrationiced and filtered
9. 9
   Lavagethe recovered product was washed with tetrahydrofuran
10. 10
    Autredried

Mode opératoire

2.85 ml of a 6.4N hydrogen chloride solution in ethanol were added to a solution of 5.1 g of the product of Example 6 in 5.1 ml of ethanol and then isopropyl ether was added thereto. The mixture was filtered and the recovered product was empasted several times with isopropyl ether, filtered and was dried. The product was dissolved in 350 ml of tetrahydrofuran and the solution was filtered and concentrated to a volume of 75 ml. The mixture was cooled, iced and filtered and the recovered product was washed with tetrahydrofuran and dried to obtain 3.3 g of 3-ethyl-5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole hydrochloride melting towards 150° C. with decomposition.

Source