Réaction #468782

Équation de réaction

3,9-dimethylbenzo[f]quinazolin-1(2H)-one

NaH

Bromomethyl methyl ether

→

3,9-dimethyl-2-methoxymethylbenzo[f]quinazolin-1(2H)-one

Solvants

DMF

water

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGthe solution was stirred at room temperature overnight
2. 2
   Extractionextracted twice with methylene chloride (100, 40 ml)
3. 3
   LavageThe combined methylene chloride extracts were washed with a small volume of water
4. 4
   Séchagedried (K2CO3)
5. 5
   Concentrationconcentrated in vacuo
6. 6
   AutreThe residue was purified by silica gel (4 0 g) chromatography
7. 7
   Lavageeluting with ethyl acetate

Mode opératoire

To a suspension of 3,9-dimethylbenzo[f]quinazolin-1(2H)-one (1.0 g, 4.5 mmol) in DMF (25 ml) was added 80% NaH (0.15 g, 5.0 mmol) (Aldrich) portion wise and the mixture was stirred 35 minutes. Bromomethyl methyl ether (0.39 ml, 4.8 mmol) (Aldrich) was added in one portion and the solution was stirred at room temperature overnight. The solution was then diluted with water (100 ml) and extracted twice with methylene chloride (100, 40 ml). The combined methylene chloride extracts were washed with a small volume of water, dried (K2CO3), and concentrated in vacuo. The residue was purified by silica gel (4 0 g) chromatography eluting with ethyl acetate:methylene chloride (0 to 1:19) to give 3,9-dimethyl-2-methoxymethylbenzo[f]quinazolin-1(2H)-one and the corresponding O-alkylated material in a 4:1 ratio as determined by NMR (0.79 g). 1H NMR (DMSO-d6, 300 MHz) for major isomer δ: 2.57 (s, 3H, C9—CH3), 2.68 (s, 3H, C3—CH3), 3.38 (s, 3H, OCH3), 5.62 (s, 2H, NCH2O), 7.51 (dd, J=8,2 Hz, 1H, Ar), 7.56 (d, J=9 Hz, 1H, Ar), 7.96 (d, J=8 Hz, 1H, Ar), 8.24 (d, J=9 Hz, 1H, Ar), 9.63 (s, 1H, Ar). Anal. Calculated for C16H6N2O2: C, 71.62; H, 6.01; H, 10.44. Found: C, 71.55; H, 6.03; H, 10.43.

Source