Réaction #468380

ord-acae6ebb88f84ece86b596f4d4674f55

Équation de réaction

CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
prochlorperazine
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate
→
CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1.CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
Apomorphine Prochlorperazine

Réactifs

CN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1
prochlorperazine
OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO
mannitol
CCCCCCCCCCCCCCCCCC(=O)[O-].CCCCCCCCCCCCCCCCCC(=O)[O-].[Mg+2]
magnesium stearate

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    workup.ADDITIONmixed for about 5 minutes in a V-shaped blender

Mode opératoire

Separately, prochlorperazine was added to and blended with the mannitol (Part B). Parts A and B were then combined and mixed for about 5 minutes in a V-shaped blender. Next, magnesium stearate was added to the blender, followed by continued blending for about 2 minutes.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US06306437B1uspto-grants-2001_10