Réaction #46786

Équation de réaction

4-Chloro-phenylamine

pyridine

bromo-acetyl bromide

→

2-Bromo-N-(4-Chloro-phenyl)-acetamide

Solvants

toluene

toluene

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONwere added dropwise under ice cooling
2. 2
   AutreAfter 2 h the precipitate was isolated by filtration
3. 3
   Autrerecrystallized from toluene
4. 4
   Autreto yield a white solid

Mode opératoire

To a solution of 5 g 4-Chloro-phenylamine and 1.5 mL pyridine in 30 mL toluene, 8 g bromo-acetyl bromide dissolved in 10 mL toluene were added dropwise under ice cooling. After 2 h the precipitate was isolated by filtration and recrystallized from toluene to yield a white solid.

Source