Réaction #46768

Équation de réaction

2-bromo-phenethylamine

triethylamine

menthoyl chloride

→

oil

Rendement 98.3%

2-Isopropyl-5-methyl-cyclohexanecarboylic acid [2-(2-bromo-phenyl)-ethyl]-amide

Rendement 98.3%

Solvants

CH2Cl2

CH2Cl2

Conditions de réaction

Traitement

1. 1
   AutreA 100 mL round bottom flask equipped with a stir bar
2. 2
   Lavagewashed with water (3×100 mL)
3. 3
   SéchageOrganic layer was dried over anhydrous sodium sulfate
4. 4
   Concentrationconcentrated under reduced pressure

Mode opératoire

A 100 mL round bottom flask equipped with a stir bar was charged with CH2Cl2 (30 mL), 2-bromo-phenethylamine (1.0 g, 5.00 mmol) and triethylamine (684 μl, 5.05 mmol). The reaction solution was treated with menthoyl chloride (1.02 g, 5.05 mmol) in one portion and stirred at ambient temperature for 30 minutes. The reaction was diluted with CH2Cl2 (50 mL) and washed with water (3×100 mL). Organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give a thick oil (1.8 g). Product was used for next step without purification.

Source