Réaction #46756

ord-34d4b82d37d54495b5bc982f2f768f38

Équation de réaction

CC1CCC(C(C)C)C(C(=O)O)C1
Menthane-3-carboxylic acid
O=S(Cl)Cl
thionyl chloride
→
CC1CCC(C(C)C)C(C(=O)Cl)C1
Menthane-3-carbonyl chloride

Réactifs

CC1CCC(C(C)C)C(C(=O)O)C1
Menthane-3-carboxylic acid
O=S(Cl)Cl
thionyl chloride

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    AutreThe SOCl2 was removed by distillation
  2. 2
    workup.DISTILLATIONthe acid chloride was distilled at 114-115° C. (8 Torr)

Mode opératoire

Menthane-3-carboxylic acid (54.35 g) was refluxed with 80 ml of thionyl chloride for 3 hours. The SOCl2 was removed by distillation, and the acid chloride was distilled at 114-115° C. (8 Torr). (Lit. b.p. 84-85° C. at 3.5 Torr). Yield: 50 g (84%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07741355B2uspto-grants-2010_06