Réaction #464770

Équation de réaction

HCl

1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester

ethanol

potassium hydroxide

→

title compound

Rendement 93.1%

1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid

Rendement 93.1%

Solvants

water

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed
2. 2
   Températurewith heat for 1.5 hours
3. 3
   Autreto obtain a precipitated crystal
4. 4
   Filtrationby filtration
5. 5
   AutreThe crystal obtained
6. 6
   Autrewas recrystallized from ethanol

Mode opératoire

A mixture of 1,2-dihydro-4-phenyl-2-oxo-3-quinoline carboxylic acid ethyl ester (5 g, 17 mmol), ethanol (20 ml), water (40 ml) and potassium hydroxide (5 g, 89 mmol) was refluxed with heat for 1.5 hours. To the reaction mixture was added 60 ml of 2N-HCl to acidify the mixture to obtain a precipitated crystal by filtration. The crystal obtained was recrystallized from ethanol to give 4.2 g (yield: 92.9%) of the title compound.

Source