Réaction #4641

ord-7f10f021005f4af18df8b64a1ea0e211

Équation de réaction

COC(=O)c1ccc(OCC2CO2)cc1O
4-(2,3-epoxypropoxy)salicylic acid methyl ester
CC(COc1ccc(O)c(C(N)=O)c1)NCc1ccccc1
5-(2-benzylaminopropoxy)salicylamide
COC(=O)c1ccc(OCC(O)CN(Cc2ccccc2)C(C)COc2ccc(O)c(C(N)=O)c2)cc1O
1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-(3-hydroxy-4-methoxycarbonylphenoxy)propan-2-ol

Solvants

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

After 40 hours' boiling and working up analogously to Example (4a), 22.4 g of 4-(2,3-epoxypropoxy)salicylic acid methyl ester and 30 g of 5-(2-benzylaminopropoxy)salicylamide in 200 ml of isopropanol yield crude 1-[N-[2-(3-carbamoyl-4-hydroxyphenoxy)-1-methylethyl]benzylamino]-3-(3-hydroxy-4-methoxycarbonylphenoxy)propan-2-ol as a light-coloured foam which is further processed as a crude product.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US04727067uspto-grants-1988_02