Réaction #46168

Équation de réaction

Hydroxy amine

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile

hydrochloric acid

pyridine

→

1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile

Rendement 45.0%

Solvants

ethanol

Conditions de réaction

Traitement

1. 1
   ExtractionThe organic layer extracted with ethyl acetate
2. 2
   Lavagewas washed with distilled water
3. 3
   Séchagedried over anhydrous magnesium sulfate
4. 4
   Concentrationconcentrated
5. 5
   Autrethe resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2)

Mode opératoire

1-Oxo-3-phenyl-6-(3-phenylpropoxy)-1H-indene-2-carbonitrile (200 mg, 0.547 mmol) was dissolved in ethanol. Hydroxy amine.hydrochloric acid (114 mg, 1.64 mmol) and pyridine (173 mg, 2.18 mmol) were added thereto and the mixture was stirred for 4 hours at 70° C. The organic layer extracted with ethyl acetate was washed with distilled water, dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography (ethyl acetate:hexane=1:2) to obtain trails 1-hydroxy imino-3-phenyl-6-(3-phenylpropyloxy)-1H-indene-2-carbonitrile (95 mg, yield 45%) as a red solid,

Source