Réaction #46157

Équation de réaction

Piperonyl alcohol

Triethylamine

thionyl chloride

→

5-chloromethyl benzo[1,3]dioxol

Rendement 100.0%

Solvants

benzene

Conditions de réaction

Traitement

1. 1
   ExtractionThe reaction mixture was extracted with sodium bicarbonate and ethyl acetate
2. 2
   Autrethe organic layer was separated
3. 3
   Séchagedried over anhydrous magnesium sulfate

Mode opératoire

Piperonyl alcohol (10 g, 65.7 mmol) was dissolved in benzene. Triethylamine (11 ml, 78.8 mmol) and thionyl chloride (11 ml, 131.4 mmol) were added dropwise thereto and was stirred for 24 hours at 0° C. The reaction mixture was extracted with sodium bicarbonate and ethyl acetate, the organic layer was separated, and dried over anhydrous magnesium sulfate to obtain 5-chloromethyl benzo[1,3]dioxol (11.2 g, yield 100%).

Source