Réaction #45963

Équation de réaction

nitro

1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene

→

4-[4-fluoro-3-(trifluoromethyl)phenoxy]aniline

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture was then filtered
2. 2
   Autreto remove the catalyst
3. 3
   AutreThe solvent was removed in vacuuo

Mode opératoire

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (10 mg) until completion, as indicated by TLC or HPLC, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford the desired 4-[4-fluoro-3-(trifluoromethyl)phenoxy]aniline, which was used directly for further transformation without further purification.

Source