Réaction #45950

Équation de réaction

nitro

1-fluoro-4-(4-nitrophenoxy)-2-(trifluoromethyl)benzene

→

4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline

Rendement 95.0%

Solvants

MeOH

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture was then filtered
2. 2
   Autreto remove the catalyst
3. 3
   AutreThe solvent was removed in vacuuo

Mode opératoire

The nitro intermediate (2 mmol) obtained above was dissolved in MeOH (10 mL) and hydrogenated in the presence of 10% Pd/C (50 mg) until completion as indicated by TLC or LC-MS, according to General Procedure H. The reaction mixture was then filtered to remove the catalyst. The solvent was removed in vacuuo to afford 4-(4′-fluoro-3′-trifluoromethyl-phenoxy)aniline, which was used directly for further transformation without purification (overall yield: 95%).

Source