Réaction #4577

Équation de réaction

methyl 5-chlorooxindole-3-carboxylate

phenylisocyanate

→

Methyl 1-N-(phenyl)carbamoyl-5-chlorooxindole-3-carboxylate

Solvants

toluene

—

petroleum ether

Conditions de réaction

Traitement

1. 1
   Températureheated
2. 2
   Températureto reflux overnight
3. 3
   TempératureThe reaction mixture was cooled
4. 4
   Autreto give
5. 5
   Filtrationafter filtration
6. 6
   Autredrying

Mode opératoire

To 6.0 g. (0.027 mole) of methyl 5-chlorooxindole-3-carboxylate in 200 ml. of toluene was added 5.25 ml. (0.048 mole) of phenylisocyanate and the resulting reaction mixture heated to reflux overnight. The reaction mixture was cooled and diluted with petroleum ether to give, after filtration and drying, 2.0 g. of the desired product.

Source