Réaction #45733

Équation de réaction

ethyl acetate

6-Bromo-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

3-aminophenylboronic acid monohydrate

tripotassium phosphate

→

6-(3-Aminophenyl)-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile

Solvants

1,4-dioxane

brine

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling to room temperature
2. 2
   ExtractionThe aqueous layer was extracted twice with ethyl acetate
3. 3
   Lavagewashed with saturated brine
4. 4
   Séchagedried over anhydrous sodium sulfate
5. 5
   AutreThe insoluble matter was separated by filtration
6. 6
   Autrethe solvent was evaporated away
7. 7
   Autrethe resulting residue was purified by middle-pressure liquid chromatography (eluent, hexane:ethyl acetate=2:1)
8. 8
   Autreto obtain the entitled compound (170 mg, quant.) as a white amorphous substance

Mode opératoire

6-Bromo-2-cyclopropyl-7-fluoro-5-methyl-1,3-benzoxazole-4-carbonitrile (I-77) (150 mg, 0.51 mmol) and 3-aminophenylboronic acid monohydrate (315 mg, 2.03 mmol) were dissolved in 1,4-dioxane (5 ml), then at room temperature, tripotassium phosphate (216 mg, 1.02 mmol) and then tetrakis(triphenylphosphine)palladium(0) (118 mg, 0.10 mmol) were added. The suspension was stirred under nitrogen atmosphere at 95° C. for 12 hours. After cooling to room temperature, the solution was fractionated with ethyl acetate and saturated brine. The aqueous layer was extracted twice with ethyl acetate. The organic layers were combined, washed with saturated brine, and dried over anhydrous sodium sulfate. The insoluble matter was separated by filtration, the solvent was evaporated away, and the resulting residue was purified by middle-pressure liquid chromatography (eluent, hexane:ethyl acetate=2:1) to obtain the entitled compound (170 mg, quant.) as a white amorphous substance.

Source