Réaction #45602

Équation de réaction

Triethylamine

3-methylaminoazetidine hydrochloride trifluoroacetate

2-tert-butyl-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile

sodium bicarbonate water

3-methylaminoazetidine hydrochloride trifluoroacetate

triethylamine

→

compound

Rendement 69.4%

2-tert-Butyl-5-methyl-7-(3-methylaminoazetidin-1-yl)-6-phenyl-1,3-benzoxazole-4-carbonitrile

Rendement 69.4%

Solvants

dimethyl sulfoxide

brine

Conditions de réaction

Traitement

1. 1
   workup.STIRRINGby stirring at 90° C. for 8 hours
2. 2
   TempératureAfter cooling
3. 3
   Extractionthis was extracted with ethyl acetate and chloroform
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated under reduced pressure
6. 6
   AutreThe resulting residue was purified by silica gel column chromatography (chloroform:methanol-100:1)

Mode opératoire

Triethylamine (316 μl, 2.27 mmol) and 3-methylaminoazetidine hydrochloride trifluoroacetate (140 mg, 590 μmol) were added to a dimethyl sulfoxide (3.5 ml) solution of 2-tert-butyl-7-fluoro-5-methyl-6-phenyl-1,3-benzoxazole-4-carbonitrile (I-72) (140 mg, 454 μmol), followed by stirring overnight at 90° C., then 3-methylaminoazetidine hydrochloride trifluoroacetate (53.7 mg, 227 μmol) and triethylamine (63.3 μl, 454 μmol) were added, followed by stirring at 90° C. for 8 hours. After cooling, saturated sodium bicarbonate water and saturated brine were added to the reaction liquid, and this was extracted with ethyl acetate and chloroform. The organic layers were combined, dried over anhydrous magnesium sulfate, concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (chloroform:methanol-100:1) to obtain the entitled compound (118 mg, 69%) as a pale yellow solid.

Source