Réaction #45295

Équation de réaction

t-Butylamine

m-chloro-α-bromopropiophenone

→

bupropion

Conditions de réaction

Traitement

1. 1
   Autreobtained above and the reaction mixture
2. 2
   Températurewas refluxed for 3 hours
3. 3
   AutreExcessive t-butylamine was removed by evaporation below 80° C
4. 4
   Extractionextracted with 800 ml of ethyl acetate and 280 ml of water
5. 5
   SéchageThe organic phase was dried with anhydrous magnesium sulfate (15 g)

Mode opératoire

t-Butylamine was added to m-chloro-α-bromopropiophenone obtained above and the reaction mixture was refluxed for 3 hours. Excessive t-butylamine was removed by evaporation below 80° C. The concentrated solution was cooled down to room temperature and then extracted with 800 ml of ethyl acetate and 280 ml of water. The organic phase was dried with anhydrous magnesium sulfate (15 g) to obtain a solution of bupropion free base. A solution of HCl in ethyl acetate was added at room temperature to the organic phase. Crude product of bupropion hydrochloride was obtained after filtration. The crude product of bupropion hydrochloride was dissolved in 1200 ml of methanol and 120 ml of water at 80° C., decolorized with activated carbon (5 g) for 20 minutes and filtered. The filtrate was cooled and filtered to obtain wet product of bupropion hydrochloride. The wet product was dried in vacuum (−0.04˜−0.09 MPa, 80° C.) for 3 hours to obtain pure product. Total yield was 70% based on m-chloropropiophenone, and the HPLC's purify was higher than or equal to 99.9%.

Source