Réaction #452415

Équation de réaction

3-(n-butylamino)phenol

2-bromoethanol

NaHCO3

→

3-[N-(n-butyl)-N-(2-hydroxyethyl)amino]phenol

Rendement 54.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling
2. 2
   Filtrationthe mixture is filtered
3. 3
   Autrethe solvent is removed in vacuo

Mode opératoire

0.1 mol of 3-(n-butylamino)phenol in 100 ml of methanol is refluxed for 10 h with 0.11 mol of 2-bromoethanol and 0.1 mol of NaHCO3. After cooling, the mixture is filtered, the solvent is removed in vacuo, and the residue is fractionated, to give 3-[N-(n-butyl)-N-(2-hydroxyethyl)amino]phenol.

Source