Réaction #4519

Équation de réaction

palmitoyl-L-Ala-D-Glu(OH)OBzl

N-hydroxysuccinimide

dicyclohexylcarbodiimide

→

palmitoyl-L-Ala-D-Glu(OSu)OBzl

Solvants

tetrahydrofuran

chloroform

Conditions de réaction

Traitement

1. 1
   Filtrationthe precipitate was filtered off
2. 2
   Lavagewashed with chloroform
3. 3
   ConcentrationThe filtrate was concentrated in vacuo
4. 4
   workup.ADDITIONthe diisopropylether was added to the residue
5. 5
   AutreThe product was collected
6. 6
   Autredried

Mode opératoire

To a solution of palmitoyl-L-Ala-D-Glu(OH)OBzl (1)(1.84 g) in a mixture of tetrahydrofuran (20 ml) and chloroform (30 ml) were added N-hydroxysuccinimide (425 mg) and dicyclohexylcarbodiimide (728 mg). The reaction mixture was kept for 18 hours at room temperature and the precipitate was filtered off and washed with chloroform. The filtrate was concentrated in vacuo and the diisopropylether was added to the residue. The product was collected and dried to afford palmitoyl-L-Ala-D-Glu(OSu)OBzl (2)(170 g).

Source