Réaction #4476

Équation de réaction

water

potassium carbonate

product

1,2,3,9-Tetrahydro-6-methoxy-4H-carbazol-4-one

Dimethyl sulphate

→

title compound

Rendement 78.2%

1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

Rendement 78.2%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   Températurethe mixture was heated
2. 2
   Températureto reflux for 4 h
3. 3
   Filtrationthe resulting precipitate filtered off

Mode opératoire

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

Source