Réaction #44753

Équation de réaction

4-bromophenol

4-fluorobenzaldehyde

potassium carbonate

→

4-(4-bromophenoxy)benzaldehyde

Solvants

DMF

Conditions de réaction

Traitement

1. 1
   TempératureAfter cooling to ambient temperature

Mode opératoire

The mixture of 4-bromophenol (10 g, 57.8 mmol), 4-fluorobenzaldehyde (7.17 g, 57.9 mmol), and potassium carbonate (12 g, 86.7 mmol) in DMF was heated at 170° C. for 4 hours. After cooling to ambient temperature, the reaction mixture was poured into ice-water. The resulting solid, 4-(4-bromophenoxy)benzaldehyde, was isolated by filtration (15 g, 94%), 1H NMR (CDCl3) δ 9.95 (s, 1H), 7.85 (d, 2H), 6.62 (d, 2H), 7.17 (d, 2H), 6.96 (d, 2H) ppm.

Source