Réaction #4467

Équation de réaction

potassium carbonate

n-butyl 2-tert-butoxyacetate

→

title compound

2-tert-Butoxyacetic acid

Solvants

methanol water

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was heated
2. 2
   Températureat reflux for 17 hours
3. 3
   Autrethe volatiles removed on a flash evaporator
4. 4
   ExtractionThe product was extracted with ether
5. 5
   Extractionthe ether extract
6. 6
   Lavagewashed with brine
7. 7
   Séchagedried over magnesium sulfate
8. 8
   Concentrationconcentrated in vacuo

Mode opératoire

To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.

Source