Réaction #445287

Équation de réaction

Dioxolane

tetraethylammonium fluoride dihydrate

acetic acid

tetrahydrofuran

→

3-(4-Methyl-2-oxo-1,3-dioxolan-4-yl)-4-(2-oxopropyl)-2-azetidinone

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Lavagewashed with saturated saline
2. 2
   Autredried
3. 3
   Concentrationconcentrated
4. 4
   AutreThe residue purified by silica gel chromatography
5. 5
   Autreto give
6. 6
   Lavageeluted with benzene-ethyl acetate (1:5)

Mode opératoire

A mixture of Dioxolane (B-5)(1.62 g), tetraethylammonium fluoride dihydrate (1.38 g) and acetic acid (0.5 ml) in tetrahydrofuran (10 ml) is stirred at room temperature for 2 hours. The reaction mixture is diluted with ethyl acetate (50 ml), washed with saturated saline, dried and concentrated. The residue purified by silica gel chromatography to give tilted Lactam (C-5)(895 mg) from the fractions eluted with benzene-ethyl acetate (1:5).

Source