Réaction #44362

Équation de réaction

Morpholine

[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride

Water

→

sub-title compound

4-[[4-Bromo-2-(trifluoromethyl)phenyl]sulfonyl]morpholine

Solvants

DCM

Conditions de réaction

Traitement

1. 1
   Extractionthe mixture was extracted with DCM
2. 2
   SéchageThe organic extracts were dried (MgSO4)
3. 3
   Autreevaporated
4. 4
   Autrepurified by chromatography (silica, petrol-ether as eluent)

Mode opératoire

Morpholine (1.1 ml) was added to a solution of [4-bromo-2-(trifluoromethyl)phenyl]sulfonyl chloride (2.03 g) in DCM (7 ml) at 0° C. and stirred at 20° C. for 16 h. Water was added and the mixture was extracted with DCM. The organic extracts were dried (MgSO4), evaporated and purified by chromatography (silica, petrol-ether as eluent) to give the sub-title compound 2.10 g).

Source