Réaction #44316

Équation de réaction

N-BOC-1,4-diaminobutane

maleic anhydride

→

title compound

(4-Maleimidyl-butyl)-carbamic acid tert-butyl ester

Solvants

toluene

Conditions de réaction

Traitement

1. 1
   Températurethe solution heated
2. 2
   Températureat reflux under Dean-Stark conditions for two days
3. 3
   AutreThe solvent was removed
4. 4
   Autrethe residue purified by silica column chromatography
5. 5
   Lavageeluting with 25-40% ethyl acetate in hexane

Mode opératoire

To a solution of N-BOC-1,4-diaminobutane (8.324 g, 0.044 mol) in dry toluene (50 ml) was added maleic anhydride (4.336 g, 0.044 mol) and the solution heated at reflux under Dean-Stark conditions for two days. The solvent was removed and the residue purified by silica column chromatography eluting with 25-40% ethyl acetate in hexane to give the title compound, 1.461 g, 12%, as a white solid.

Source