Réaction #44188

Équation de réaction

4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester

NCS

→

4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester

Rendement 95.0%

Solvants

EtOAc

DMF

Conditions de réaction

Traitement

1. 1
   Lavagewashed with 0.1 N HCl solution
2. 2
   SéchageThe organic layer was dried (MgSO4)
3. 3
   Concentrationconcentrated under reduced pressure

Mode opératoire

A mixture of 4-chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester (1.00 g, 4.64 mmol) and NCS (0.68 g, 5.10 mmol) in DMF (30 mL) was stirred for 1 hour. The reaction mixture was diluted with EtOAc and washed with 0.1 N HCl solution. The organic layer was dried (MgSO4) and concentrated under reduced pressure to give 1.10 g (95%) of 4,5-dichloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid ethyl ester.

Source