Réaction #44153

Équation de réaction

3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline

triethylamine

methanesulfonyl chloride

→

title compound

N-(3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-N-(methylsulfonyl)methanesulfonamide

Solvants

DCM

Conditions de réaction

Traitement

1. 1
   Autrepartitioned between saturated aqueous sodium hydrogencarbonate solution and DCM
2. 2
   LavageThe organic layer was washed with water
3. 3
   Autredried
4. 4
   Concentrationconcentrated in vacuo
5. 5
   AutreThe residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)]

Mode opératoire

To a stirred solution of 3-{2-[4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}aniline (370 mg) and triethylamine (178 μL) in DCM (3 mL) was added methanesulfonyl chloride (33 L). The mixture was stirred for 18 h, then partitioned between saturated aqueous sodium hydrogencarbonate solution and DCM. The organic layer was washed with water, dried and concentrated in vacuo. The residue was purified by column chromatography [SiO2; DCM-MeOH, (20:0)→(20:1)] to give the title compound (342 mg).

Source