Réaction #44122

Équation de réaction

Trimethylsilyl chloride

(3-nitrophenyl)acetic acid

→

title compound

Rendement 100.0%

Methyl (3-nitrophenyl)acetate

Rendement 100.0%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   Concentrationconcentrated at reduced pressure
2. 2
   Autrepartitioned between DCM and aqueous sodium hydrogencarbonate solution
3. 3
   SéchageThe organic phase was dried over sodium sulfate
4. 4
   Filtrationfiltered
5. 5
   Concentrationconcentrated under vacuum

Mode opératoire

Trimethylsilyl chloride (5.6 mL, 2.0 equiv.) was added to a stirred solution of (3-nitrophenyl)acetic acid (4.0 g) in methanol (60 ml). The resulting solution was stirred at room temperature for 18 hours, then concentrated at reduced pressure and partitioned between DCM and aqueous sodium hydrogencarbonate solution. The organic phase was dried over sodium sulfate, filtered and concentrated under vacuum to give the title compound as a colourless liquid (4.2 g, 100%).

Source