Réaction #44044

Équation de réaction

DMF-DMA

hydrazine hydrate

2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one

compound 126

cis-7,9-diethyl-1,4-dioxa-8-azaspiro[4.5]decane

pyridine-2-sulfonyl chloride hydrochloride

pyrazole

→

cis-4,6-Diethyl-5-(pyridin-2-ylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine

Conditions de réaction

Mode opératoire

Prepared by treatment of 2,6-diethyl-1-(pyridin-2-ylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using pyridine-2-sulfonyl chloride hydrochloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15,

Source