Réaction #44043

ord-f36e63dddc5a4ca780a01bff8d78ffd5

Équation de réaction

O=S(=O)(c1ccc(Cl)cc1)N1CCc2[nH]ncc2C1CO
(5-(4-chlorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-4-yl)methanol
CN(C)C(=O)Cl
dimethylcarbamyl chloride
CCC1CC2(CC(CO)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2
compound 111
CCC1CC2(CC(CO)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2
(8-(4-chlorophenylsulfonyl)-9-ethyl-1,4-dioxa-8-azaspiro[4.5]decan-7-yl)methanol
→
CN(C)C(=O)OCC1c2cn[nH]c2CCN1S(=O)(=O)c1ccc(Cl)cc1
(5-(4-Chlorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-4-yl)methyl dimethylcarbamate

Réactifs

O=S(=O)(c1ccc(Cl)cc1)N1CCc2[nH]ncc2C1CO
(5-(4-chlorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-4-yl)methanol
CN(C)C(=O)Cl
dimethylcarbamyl chloride
CCC1CC2(CC(CO)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2
compound 111
CCC1CC2(CC(CO)N1S(=O)(=O)c1ccc(Cl)cc1)OCCO2
(8-(4-chlorophenylsulfonyl)-9-ethyl-1,4-dioxa-8-azaspiro[4.5]decan-7-yl)methanol

Réactifs

Aucun

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Mode opératoire

Prepared by treatment of (5-(4-chlorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-4-yl)methanol with dimethylcarbamyl chloride as described for compound 111 in Example 14.

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07732609B2uspto-grants-2010_06