Réaction #43923

Équation de réaction

ethyl 4-chloroacetoacetate

resorcinol

→

title compound

Rendement 84.0%

4-(chloromethyl)-7-hydroxy-2H-chromen-2-one

Rendement 84.0%

Solvants

sulfuric acid

Conditions de réaction

Traitement

1. 1
   TempératureUnder ice-cooling
2. 2
   Filtrationthe precipitated solid was collected by filtration
3. 3
   Lavagewashed with water
4. 4
   Autreair-dried

Mode opératoire

Under ice-cooling, ethyl 4-chloroacetoacetate (14.0 g, 85.0 mmol) was dissolved in concentrated sulfuric acid (30 mL), resorcinol (8.81 g, 80.0 mmol) was added by small portions, and the mixture was stirred at room temperature for 2 hr. The reaction mixture was poured into ice water, and the precipitated solid was collected by filtration, washed with water, and air-dried to give the title compound (14.1 g, yield 84%) as a beige powder.

Source