Réaction #4390

Équation de réaction

2-amino-3-chloropyrazine

2-methylbenzylamine

potassium carbonate

potassium iodide

→

2-amino-3-(2-methylbenzylamino)pyrazine

Rendement 19.7%

Solvants

water

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   Températurewas refluxed for 24 hours under a nitrogen atmosphere
2. 2
   Autreto stand at room temperature
3. 3
   Extractionextracted with ethyl acetate
4. 4
   LavageThe extract was washed with water
5. 5
   Séchagedried over magnesium sulfate
6. 6
   Autreevaporated in vacuo
7. 7
   AutreThe residue was purified by column chromatography on silica gel (110 g) with a mixture of chloroform and methanol (100:3) as an eluent

Mode opératoire

A mixture of 2-amino-3-chloropyrazine (4.3 g), 2-methylbenzylamine (4.6 g), potassium carbonate (5.5 g), and potassium iodide (0.4 g) in N,N-dimethylformamide (43 ml) was refluxed for 24 hours under a nitrogen atmosphere and allowed to stand at room temperature. The mixture was poured into water and extracted with ethyl acetate. The extract was washed with water, dried over magnesium sulfate, and evaporated in vacuo. The residue was purified by column chromatography on silica gel (110 g) with a mixture of chloroform and methanol (100:3) as an eluent to give 2-amino-3-(2-methylbenzylamino)pyrazine (1.4 g).

Source