Réaction #4389

Équation de réaction

2-Amino-3-chloropyrazine

2-methylbenzyl alcohol

sodium hydride

→

2-amino-3-(2-methylbenzyloxy)pyrazine

Rendement 41.5%

Solvants

N,N-dimethylformamide

Conditions de réaction

Traitement

1. 1
   workup.ADDITIONpoured
2. 2
   Autreonto crushed ice
3. 3
   AutreThe resulting precipitates
4. 4
   Filtrationwere collected by filtration
5. 5
   Lavagewashed with n-hexane
6. 6
   Autredried in a desiccator

Mode opératoire

To a solution of 2-methylbenzyl alcohol (0.985 g) in N,N-dimethylformamide (10 ml) was added 62.8% sodium hydride (0.308 g) under a nitrogen atmosphere and then stirred for 30 minutes. 2-Amino-3-chloropyrazine (0.87 g) was added to the solution and the mixture was heated at 65° C. for 2 hours and poured onto crushed ice. The resulting precipitates were collected by filtration, washed with n-hexane, and dried in a desiccator to give 2-amino-3-(2-methylbenzyloxy)pyrazine (0.6 g).

Source