Réaction #43812

ord-7127dda99fa6496f990591c54edd8f2f

Équation de réaction

CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
product
CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester
→
CCCc1nc2cc(N)ccc2n1CC(=O)OC(C)(C)C
sub-title compound
CCCc1nc2cc(N)ccc2n1CC(=O)OC(C)(C)C
(5-Amino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Réactifs

CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
product
CCCc1nc2cc(NC(=O)OC(C)(C)C)ccc2n1CC(=O)OC(C)(C)C
(5-tert-Butoxycarbonylamino-2-propyl-benzoimidazol-1-yl)-acetic acid tert-butyl ester

Réactifs

Aucun

Solvants

Cl
HCl
C1COCCO1
dioxane

Conditions de réaction

Conditions détaillées
See reaction.notes.procedure_details.

Traitement

  1. 1
    ConcentrationThe reaction was concentrated

Mode opératoire

The product of example 25, step d.) (140 mg, 0.359 mmol) was stirred in 4 M HCl in dioxane (1 mL) at ambient temperature for an hour. The reaction was concentrated to give the sub-title compound that was used in crude form without purification. MS: ESI (positive): 290 (M+H).

Source

DOI: 10.6084/m9.figshare.5104873.v1Brevet: US07732618B2uspto-grants-2010_06