Réaction #4376

Équation de réaction

3-methoxybenzeneacetic acid

iodine monochloride

water

→

2-iodo-5-methoxybenzeneacetic acid

Rendement 65.0%

Solvants

acetic acid

Conditions de réaction

Traitement

1. 1
   Autrethe solid collected
2. 2
   AutreIt was recrystallized from toluene

Mode opératoire

A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).

Source