Réaction #43446

Équation de réaction

bromomaleic anhydride

Hydrazine sulphate salt

bromomaleic anhydride

hydrazine sulphate

→

4-bromo-1,2-dihydro-3,6-pyridazinedione

Rendement 151.0%

Solvants

water

water

Conditions de réaction

Traitement

1. 1
   Températureheated
2. 2
   Températureto reflux
3. 3
   TempératureThe mixture was heated
4. 4
   Températureat reflux for 4 hours
5. 5
   FiltrationThe precipitates were collected by filtration
6. 6
   Lavagewashed with water and acetone
7. 7
   Autredried as a combined batch in vacuo

Mode opératoire

Hydrazine sulphate salt (51 g) was suspended in water (250 ml), heated to reflux and bromomaleic anhydride (90.38 g) was added dropwise. The mixture was heated at reflux for 4 hours then cooled to room temperature. The reaction was repeated with 29 g hydrazine sulphate, 53 g bromomaleic anhydride and 130 ml water. The precipitates were collected by filtration, washed with water and acetone and dried as a combined batch in vacuo to afford 4-bromo-1,2-dihydro-3,6-pyridazinedione as a white solid (113 g).

Source