Réaction #433594

Équation de réaction

hydrazine hydrate

4-(phenylamino)-6-nitroquinazoline

iso-propylalcohol

→

4-(phenylamino)-6-aminoquinazoline

Solvants

ethanol water

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction mixture is filtered
2. 2
   Autreevaporated
3. 3
   Autrepurified by silica gel chromatography

Mode opératoire

A solution of 4-(phenylamino)-6-nitroquinazoline in ethanol/water and a polar solvent such as iso-propylalcohol is reacted at reflux temperature with hydrazine hydrate and Raney®Nickel. The reaction mixture is filtered, evaporated and purified by silica gel chromatography, to give the product, 4-(phenylamino)-6-aminoquinazoline.

Source