Réaction #43330

Équation de réaction

2,5-dichloropyridine

potassium vinyltrifluoroborate

triethylamine

ethanol

→

title compound

Rendement 69.0%

5-chloro-2-vinylpyridine

Rendement 69.0%

Solvants

ethyl acetate

Conditions de réaction

Traitement

1. 1
   Températureunder reflux
2. 2
   Lavageby washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine
3. 3
   Séchagedrying over anhydrous sodium sulfate
4. 4
   ConcentrationConcentrating the solvent under reduced pressure
5. 5
   workup.DISTILLATIONthe resulting residue was distilled under reduced pressure (63° C., 8 mmHg)

Mode opératoire

A mixture of 2,5-dichloropyridine (10.0 g), potassium vinyltrifluoroborate (10.86 g), dichloromethane complex (2.5 g) of dichloro-1,1′-bis(diphenylphosphino)-ferrocene palladium (II), triethylamine (14.13 mL) and ethanol (150 mL) was stirred overnight under reflux. After cooling the system to room temperature, ethyl acetate was added, followed by washing with saturated aqueous sodium hydrogencarbonate solution and saturated brine and drying over anhydrous sodium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was distilled under reduced pressure (63° C., 8 mmHg) to provide the title compound (6.50 g, 69%).

Source