Réaction #43322

Équation de réaction

Potassium carbonate

sodium chlorodifluoroacetate

DMF

2-bromo-5-hydroxypyridine

→

title compound

Rendement 43.0%

2-bromo-5-difluoromethoxypyridine

Rendement 43.0%

Solvants

ether

Conditions de réaction

Traitement

1. 1
   AutreThe reaction liquid
2. 2
   Températurewas cooled to room temperature
3. 3
   Lavagewashed with water
4. 4
   Séchagedried over anhydrous magnesium sulfate
5. 5
   ConcentrationConcentrating the solvent under reduced pressure
6. 6
   Autrethe resulting residue was purified on silica gel column chromatography (C-300; hexane:ethyl acetate=100:1-100:2)

Mode opératoire

Potassium carbonate (2.4 g, 17.3 mmols) and sodium chlorodifluoroacetate (4.2 g, 27.5 mmols) were added to a DMF (20 mL) solution of 2-bromo-5-hydroxypyridine (2.4 g, 13.8 mmols) and stirred overnight at 80° C. The reaction liquid was cooled to room temperature, added ether, washed with water and dried over anhydrous magnesium sulfate. Concentrating the solvent under reduced pressure, the resulting residue was purified on silica gel column chromatography (C-300; hexane:ethyl acetate=100:1-100:2) to provide the title compound (1.32 g, 43%).

Source