Réaction #43319

Équation de réaction

4-fluorobenzyl bromide

4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one

2-fluoro-5-methanesulfonyloxymethylpyridine

4-benzyloxy-1-[5-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1H-piridin-2-one

4-benzyloxy-1-{5-[2-(1-piperidinyl)ethoxy]pyridin-2-yl}-1H-pyridin-2-one

→

title compound

4-(4-Fluorobenzyloxy)-1-{5-[2-(1-piperidinyl)-ethoxy]pyridin-2-yl}-1H-pyridin-2-one

Conditions de réaction

Mode opératoire

Example 25 was repeated except that 4-benzyloxy-1-{4-[2-(1-piperidinyl)ethoxy]phenyl}-1H-pyridin-2-one and 2-fluoro-5-methanesulfonyloxymethylpyridine were replaced with 4-benzyloxy-1-[5-(2-piperidin-1-ylethoxy)pyridin-2-yl]-1H-piridin-2-one (Example 20) and 4-fluorobenzyl bromide, to provide the title compound.

Source