Réaction #43137

Équation de réaction

3-Fluoro-4-methoxy-benzaldehyde

ammonium acetate

nitromethane

→

expected product

2-Fluoro-1-methoxy-4-(2-nitro-vinyl)-benzene

Conditions de réaction

Traitement

1. 1
   TempératureThe mixture was refluxed for 2 hours
2. 2
   AutreThe nitromethane was removed by rotary evaporation
3. 3
   Autrethe residue recrystallized from ethanol

Mode opératoire

3-Fluoro-4-methoxy-benzaldehyde (10 g) was dissolved in 100 mL of nitromethane along with 5 g of ammonium acetate. The mixture was refluxed for 2 hours. The nitromethane was removed by rotary evaporation and the residue recrystallized from ethanol to give 7.6 g of the expected product. LC-MS showed the product had the expected M+H+ of 198.

Source