Réaction #431325

Équation de réaction

aluminium trichloride

4'-[(2-(3-methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

→

4'-[(2-(3-methylbutyl)-5-hydroxy-6-methoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid

Solvants

dichloromethane

Conditions de réaction

Traitement

1. 1
   Températurethe mixture is heated
2. 2
   Températureunder reflux for 15 minutes
3. 3
   workup.DISTILLATIONThe solvent is then distilled off
4. 4
   Filtrationthe residue is filtered off under suction
5. 5
   Lavagewashed
6. 6
   Autredried
7. 7
   workup.ADDITION360 mg (62% of theoretical) of a mixture of the isomeric products
8. 8
   Autreis obtained after chromatographing over silica gel (eluting agent: dichloromethane/ethanol=9:1)

Mode opératoire

3 g of aluminium trichloride are added to a suspension of 600 mg (1.3 mmol) of 4'-[(2-(3-methylbutyl)-5,6-dimethoxy-benzimidazol-1-yl)-methyl]biphenyl-2-carboxylic acid in 50 ml of dry dichloromethane and the mixture is heated under reflux for 15 minutes. The solvent is then distilled off, the residue is filtered off under suction, washed using 30 ml of water and dried. 360 mg (62% of theoretical) of a mixture of the isomeric products is obtained after chromatographing over silica gel (eluting agent: dichloromethane/ethanol=9:1).

Source