Réaction #4303

Équation de réaction

Ether

benzyl 2-chloroethyl sulfone

isopropylamine

hydrogen chloride

→

white crystalline solid

Rendement 65.8%

N-[2-[(Phenylmethyl)sulfonyl]ethyl]-2-propanamine hydrochloride

Rendement 65.8%

Solvants

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe solvent was removed in vacuo
2. 2
   Autrethe residue was partitioned between ether and dilute sodium hydroxide
3. 3
   SéchageThe ether solution was dried over magnesium sulfate
4. 4
   Autrethe solvent was removed in vacuo
5. 5
   Autreto give an oil
6. 6
   Autrea white solid precipitated

Mode opératoire

A mixture of 51.49 g (0.236 mole) of benzyl 2-chloroethyl sulfone and 600 ml of isopropylamine was stirred at room temperature for 72 hr. The solvent was removed in vacuo, and the residue was partitioned between ether and dilute sodium hydroxide. The ether solution was dried over magnesium sulfate, and the solvent was removed in vacuo to give an oil. This was dissolved in methanol, and excess ethereal hydrogen chloride was added. Ether was added, and a white solid precipitated to give 43.11 g (65.8%) of a white crystalline solid, m.p. 180.5°-181.5° C.

Source