Réaction #4301

Équation de réaction

[(4-chlorobutyl)sulfonyl]benzene

isopropylamine

→

N-(1-Methylethyl)-4-(phenylsulfonyl)-1-butanamine hydrochloride

Rendement 30.0%

Solvants

chloroform

methanol

Conditions de réaction

Traitement

1. 1
   AutreThe residue obtained
2. 2
   Extractionthe chloroform layer was extracted with water
3. 3
   SéchageThe chloroform layer was dried
4. 4
   Filtrationfiltered
5. 5
   Autresolvent removed
6. 6
   Autreto give a dark brown oil
7. 7
   AutreThis salt was recrystallized from methanol-diethyl ether
8. 8
   Autredried in vacuo overnight at 80° C

Mode opératoire

A solution of 105.95 g (0.456 mole) [(4-chlorobutyl)sulfonyl]benzene was heated overnight at 75° C. on an autoclave in 200 ml of isopropylamine. The reaction mixture was stripped to dryness. The residue obtained was dissolved in chloroform and the chloroform layer was extracted with water. The chloroform layer was dried, filtered, and solvent removed to give a dark brown oil. The oil was dissolved in methanol and converted to the hydrochloride salt. This salt was recrystallized from methanol-diethyl ether and dried in vacuo overnight at 80° C. This gave white crystalline product, m.p. 155°-157.5° C. in 30% yield.

Source