Réaction #4285

Équation de réaction

1-chloro-3-(p-chlorophenylsulfonyl)propane

potassium phthalimide

→

2-[3-[(4-Chlorophenyl)sulfonyl]propyl]-1,3-dihydro-2H-isoindole-1,3-dione

Solvants

dimethylformamide

Conditions de réaction

Traitement

1. 1
   Autrequenched in water
2. 2
   ExtractionThe mixture was extracted with methylene chloride
3. 3
   Séchagethe methylene chloride layer dried over magnesium sulfate
4. 4
   workup.ADDITIONDiethylether and hexane were added
5. 5
   AutreThe crystalline product was recrystallized from methylene chloride diethyl ether
6. 6
   Autreto give a white crystalline product, m.p. 187.5°-188.5° C.

Mode opératoire

A solution of 17.8 g (0.07 mole) of 1-chloro-3-(p-chlorophenylsulfonyl)propane and 15.2 g (0.082 mole) of potassium phthalimide in 300 ml of dimethylformamide was stirred at 90°-110° C. for 2 hr and then quenched in water. The mixture was extracted with methylene chloride and the methylene chloride layer dried over magnesium sulfate. Diethylether and hexane were added and the solution stored at 0° C. overnight. The crystalline product was recrystallized from methylene chloride diethyl ether to give a white crystalline product, m.p. 187.5°-188.5° C.

Source