Réaction #42774

Équation de réaction

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one

N-iodosuccinimide

→

3-(4-Chlorophenyl)-7-hydroxy-8-iodo-2-isopropyl-chromen-4-one

Solvants

dichloromethane

dichloromethane

Conditions de réaction

Traitement

1. 1
   Lavagewashed with water (3×100 ml) and saturated brine (50 ml)
2. 2
   Séchagedried (MgSO4)
3. 3
   Filtrationfiltered
4. 4
   Autrethe filtrate is evaporated
5. 5
   Autreto give a pale pink solid

Mode opératoire

3-(4-Chlorophenyl)-7-hydroxy-2-isopropyl-chromen-4-one (2.3 g, 7.31 mmol) is suspended in dry dichloromethane (140 ml) at room temperature. N-iodosuccinimide (1.73 g, 7.67 mmol) is added, and the mixture is stirred vigorously at room temperature for 30 min. The mixture is diluted with dichloromethane (60 ml), washed with water (3×100 ml) and saturated brine (50 ml), dried (MgSO4) and filtered, and the filtrate is evaporated to give a pale pink solid.

Source