Réaction #4239

Équation de réaction

2-(chloromethyl)benzenesulfonamide

pyrrolidine

→

white solid

Rendement 92.8%

2-(1-Pyrrolidinylmethyl)benzenesulfonamide

Rendement 92.8%

Solvants

acetonitrile

Conditions de réaction

Traitement

1. 1
   Autrethe volatiles were removed under vacuum
2. 2
   workup.ADDITIONthe residue was treated with water (40 ml)
3. 3
   Températurechilled
4. 4
   Filtrationfiltered
5. 5
   Autredried

Mode opératoire

A solution of 2-(chloromethyl)benzenesulfonamide (2.00 g, 10 mmol) in acetonitrile (20 ml) was contacted with pyrrolidine (1.6 ml, 20 mmol). After 1.0 hr at ambient temperature, the volatiles were removed under vacuum and the residue was treated with water (40 ml) and chilled. The resulting solid was pulverized, filtered, and dried to give 2.23 g of white solid, m.p. 110°-112°.

Source