Réaction #4209

Équation de réaction

2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

sodium iodide

→

title compound

Rendement 60.4%

2-Iodo-N-[3,4-bis(phenylmethoxy)phenyl]acetamide

Rendement 60.4%

Solvants

acetone

Conditions de réaction

Traitement

1. 1
   FiltrationThe reaction was filtered hot
2. 2
   Autreto remove the sodium iodide
3. 3
   Autrea precipitate formed in the cold filtrate which
4. 4
   Autrewas collected
5. 5
   Lavagewashed with cold acetone
6. 6
   Autreto give
7. 7
   Autreupon drying

Mode opératoire

A solution of 2-chloro-N-[3,4-bis(phenylmethoxy)phenyl]acetamide (8.98 g, 23.5 mmol) and sodium iodide (3.53 g, 23.5 mmol) in acetone (75 ml) was refluxed for two hours and allowed to stand overnight at room temperature. The reaction was filtered hot to remove the sodium iodide and a precipitate formed in the cold filtrate which was collected and washed with cold acetone to give, upon drying, 6.71 g (14.2 mmol) of the title compound. A second crop was obtained from cold acetone (1.0 g).

Source