Réaction #42067

Équation de réaction

4-methyl-3-[6-(5-pyrimidinyl)pyrimidin-4-ylamino]aniline

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride

→

4-(1-methylpiperazin-4-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[6-(5-pyrimidinyl)pyrimidin-4-ylamino]phenyl}benzamide

Conditions de réaction

Traitement

1. 1
   Lavagethe resulting crude crystals were washed with ethyl acetate

Mode opératoire

This compound was prepared in the same manner as in Example 1, except that 4-methyl-3-[6-(5-pyrimidinyl)pyrimidin-4-ylamino]aniline (Reference Example 21) and 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride (Reference Example 2) were used, and that the reaction was conducted at room temperature for 17 hours and the resulting crude crystals were washed with ethyl acetate.

Source